This resource provides guidance to individuals designing and conducting serosurveys, or studies that test bodily fluids to estimate what part of the population has been vaccinated against or infected with a disease—and how many people remain susceptible. Serosurveys can:

• Involve collecting and testing testing blood or oral fluid specimens specimens to measure the amount of antigen-specific antibodies in a group of people,
• Reveal what part of the population has been exposed to an infectious disease or been protected from disease by immunizations, and
• Estimate the level of population immunity as well as gaps in immunity, such as groups of people who have not been vaccinated or previously exposed.

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This module defines serosurveys and describes the uses serosurveys.

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This module describes the steps are common to the design of any type of survey, including:

• Defining the survey objectives
• Identifying the target population
• Determining the survey design
• Choosing the specimen type

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This module describes the procedures for collecting blood specimens in the community and transporting specimens to the laboratory.

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This module describes the process of testing specimens in the laboratory and key considerations for seroprevalence studies.

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This module describes the process of monitoring quality assurance of assay testing and interpreting results from serosurveys.

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This module describes activities occurring from the time the specimens reach the laboratory following collection to the point of testing, including specimen receipt, processing, storage, and shipment.

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This module describes sampling residual blood specimens from biorepositories or health facilities to be used for serosurveys.

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